Competitive Inhibition

When competitive inhibitors compete with the substrate for a spot in the active site of the enzyme. Binds with enzyme to form EI complex

• $K_m$ increases
  • It’s harder to reach half $v_{\text{max}}$ because other competing inhibitors prevent access to the active site
• $v_{\text{max}}$ unaffected
  • With high enough $[S]$, you can achieve $v_{\text{max}}$

Lineweaver-Burk Plot