Degree Of Inhibition

$\displaystyle \alpha=\frac{K_{M}^{\text{apparent}}}{K_{M}}=1+\frac{[I]}{K_{I}}$

• $\displaystyle K_{M}^{\text{apparent}}$ is the new $\displaystyle K_{M}$ after adding the inhibitor
• $\displaystyle K_{M}$ is the Michaelis constant
• $\displaystyle K_{I}$ is the dissociation constant for the free enzyme + inhibitor complex
• $\displaystyle \alpha=1$ means no inhibition
• $\displaystyle \alpha\rightarrow \infty$ means a lot of inhibition