Noncompetitive Inhibition

#Biochemistry
Allosteric inhibitor binds equally to the enzyme and the ES complex

• $\displaystyle K_{m}$ unaffected
  • Binding affinity of the enzyme for the substrate is unaffected, so $\displaystyle K_{m}$ is also unaffected
• $\displaystyle v_{\text{max}}$ decreased
  • Less enzyme to react, so $\displaystyle v_{\text{max}}$ decreased

Lineweaver-Burk Plot

Mnemonic

• Noncompetitive sounds like no k ($\displaystyle K_{m}$ unchanged)
• N is horizontally asymmetric, which corresponds with how its reaction diagram is asymmetric