Protein Inhibition

#Biochemistry

Topics

Degree of Inhibition

Types

Competitive Inhibition
Allosteric Inhibition

$\displaystyle K_{I}=\frac{[I]}{\left( \frac{K_{M}^{\text{app}}(1+[I]/\alpha K_{I})}{K_{M}}-1 \right)}$

$\displaystyle K_{M}$ is the
$\displaystyle K_{M}^{\text{app}}$ is the apparent $\displaystyle K_{M}$ after inhibitor is added
$\displaystyle [I]$ is the concentration of inhibitor
$\displaystyle \alpha$ is how differently the enzyme binds to the enzyme substrate