Ubiquitination

#Biochemistry
The process of marking a protein with ubiquitin marks it for proteolysis

Enzymes

• E1
  • With ATP, forms thiol ester bond with ubiquitin
• E2
  • Exchanges thiol ester bond with E1
  • While connected to E3, positions ubiquitin to add to substrate/target protein
• E3
  • Recognizes degron tag on target protein