Protein Inhibition

Topics

• Degree of Inhibition

Types

• Competitive Inhibition
• Allosteric Inhibition
  • Uncompetitive Inhibition
  • Mixed Inhibition
  • Noncompetitive Inhibition

$K_I=\frac{[I]}{\left(\frac{K_M^{\text{app}}(1+[I]/\alpha K_I)}{K_M}-1\right)}$

• $K_M$ is the
• $K_M^{\text{app}}$ is the apparent $K_M$ after inhibitor is added
• $[I]$ is the concentration of inhibitor
• $\alpha$ is how differently the enzyme binds to the enzyme substrate